Kappa opioid receptors in the central amygdala modulate spinal nociceptive processing through an action on amygdala CRF neurons
نویسندگان
چکیده
منابع مشابه
Opioid Receptors of the Central Amygdala and Morphine-Induced Antinociception
The amygdala is a forebrain region, which is known as a modulator of pain sensation. The amygdala, particularly the central nucleus, has high concentrations of enkephalins relative to dynorphins and has high concentrations of opioid receptors. We here studied the role of central nuclei of amygdala in morphine antinociception. Methods: In this study, we used 130 male Wistar rats (200- 250g). Bil...
متن کاملInteraction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala.
The corticotropin-releasing factor (CRF) and kappa-opioid receptor (KOR) systems are both implicated in stress-related behaviors and drug dependence. Although previous studies suggest that antagonism of each system blocks aspects of experimental models of drug dependence, the possible interaction between these systems at the neuronal level has not been completely examined. We used an in vitro b...
متن کاملPro- and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors.
Corticotropin-releasing factor (CRF) is not only a stress hormone but also acts as a neuromodulator outside the hypothalamic-pituitary-adrenocortical axis, playing an important role in anxiety, depression, and pain modulation. The underlying mechanisms remain to be determined. A major site of extra-hypothalamic expression of CRF and its receptors is the amygdala, a key player in affect-related ...
متن کاملopioid receptors of the central amygdala and morphine-induced antinociception
the amygdala is a forebrain region, which is known as a modulator of pain sensation. the amygdala, particularly the central nucleus, has high concentrations of enkephalins relative to dynorphins and has high concentrations of opioid receptors. we here studied the role of central nuclei of amygdala in morphine antinociception. methods: in this study, we used 130 male wistar rats (200- 250g). bil...
متن کاملCentral kappa opioid receptors modulate salt appetite in rats
The role of the central opioid system in the control of water and salt intake is complex, with both stimulatory and inhibitory effects having been observed. The aim of the present study was to investigate the participation of the central κ-opioid receptors in the control of salt appetite. Male Wistar rats were submitted to two different experimental protocols: sodium deficit produced by the diu...
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ژورنال
عنوان ژورنال: Molecular Brain
سال: 2020
ISSN: 1756-6606
DOI: 10.1186/s13041-020-00669-3